Webb City fell to 15-9 overall and 5-3 in the Central Ozark Conference with Thursday's setback against Class 6 No. 7 Nixa.
After a close first half, Nixa outscored Webb City 42-17 after the break.
Webb City got a boost from its bench in the first quarter, as Malorie Stanley hit a pair of 3-pointers and Dawsyn Decker scored two hoops inside to give the Cardinals a 17-12 lead at the end of the first period.
The Eagles outscored the Cardinals 20-8 in the second period for a 32-25 halftime advantage.
The Cardinals were plagued by empty possessions and turnovers in the third period and the hosts took a double-digit lead.
Webb City received hoops from Sami Mancini, Kirra Long, Decker and Stanley late in the third quarter, cutting the visitors' deficit to 10. But Nixa scored the final seven points of the frame, five at the foul line, to take a 55-38 advantage into the fourth quarter.
The Eagles won the final period 19-4 for the final margin.
Nixa improved to 18-6 and 5-2 in the conference. Laila Grant led the Eagles with 19 points and Norah Clark added 16.
Stanley scored nine points for the Cardinals, while Kate Brownfield and Mancini added seven points apiece. Decker scored six points, while Long and Izzy Lopez added five points apiece and Mia Robbins had three.
There were 52 fouls called and the two teams combined to shoot 69 free throws. Nixa went 32-for-45 at the foul line, while Webb City made 12-of-24 at the charity stripe.
Webb City hosts Class 5 No. 1 Carl Junction on Monday night in the regular season finale for both squads.